Hello, first off I’d like to say i love your blog. Awesome stuff in here!
Anyways I’m planning on doing mushrooms and I was wondering if you have any experience with them and if so do you have any tips?
The primary psychoactive compound is Psilocybin, (4-Po-DMT) which is metabolized in vivo to (4-Ho-DMT) or psilocin. Psilocin is responsible for the majority of psychedelic action in the brain. Psilocin binds to 5ht receptors in the central nervous system (CNS) with low binding affinity making it only a partial agonist. The specificity of action, and the low binding affinity make 4 substitute dimethyl-tryptamine a reasonably safe tool for psychonautical exploration. The low binding affinity for Psilocybin and Psilocin indicates low neural toxicity. Psilocin is structurally similar to the neurotransmitter serotonin and the only significant difference is the HO molecule. Psilocybin is the prodrug of psilocin.
Psychedelic mushrooms produce 4 substitute tryptamine in differing proportions depending on various factors including but not limited to environmental conditions during growing and the strain of mushrooms in question. it is therefore extremely difficult to gauge the potency of any sample of mushrooms a priori. Two mushrooms from the same batch of the same strain can in theory have dramatically different amounts of psychoactive compounds, this makes consistent dosing extremely difficult, as the volumetric measurement of mushrooms give no indication of effect, as a consequence a dose/response curve cannot be calculated from raw material.
Psilocin produce a profound range of psychological responses. The action of drug in vivo is long in duration, making it ideal for introspection. Psilocybin has strong dissociative effects, and isolates the mind from the body. By acting on the most primitive neurological mechanism of the brain,( most notably “eat and breed”) mechanism, draws the individuals focus to security, well being, and comfort. also located in the CNS is the hippocampus, the neurological structure responsible for memory. stimulation of the hippocampus by 4-substitute Dimethyl tryptamine results in reflection and personal evaluation of ones individual experience, This makes Psilocin an effective tool in psychoanalysis and the treatment of cognitive and behavioral disorders. Psychedelic mushrooms have been effective in treating depression, and have helped terminally ill cancer patients come to accept death.
Onset of psychedelic effects is slow, as psilocybin must be metabolized in the liver into psilocin before becoming active. Onset usually occurs within 45 minutes to an hour and half with peak effects occurring within three to four hours after ingestion. effects taper off gradually over the course of several hours, the total duration of effect being 6 to 8 hours, with after effects being experienced for up to 72 hours after. long term psychological and emotional effects are unknown. as with all psychedelic compounds, great caution should be exercised, and should never be ingested under unstable conditions. Duration is effected principally by concentration of active compound in the sample, and the size of the dose taken. doses range from 1 gram, to ¼ of an ounce of dried material, with the typical range being between 2-4 grams.
The Range of effects experienced are dose dependent. Response varies from mild euphoria at low doses(1.5 to 2 g.) to full on delirium at high doses exceeding ¼ oz. Effects are highly visual, and often personal to observer. auditory effects are limited to enhancement of music. at higher doses negative effects are more likely to occur, such effects include but are not limited to; intense depersonalization, fear, paranoia, and vasoconstriction. there are no known contraindication, bad “trips” can be terminated through application of benzodiazpam, or any other GABA-ergenic compound. medicines that act on acetylcholine such as Diphenhydramine are not recommended except under extreme circumstances as their actions are broad and difficult to predict. GABAa is the antagonist of the 5ht receptor, and thus it is the diametric opposite of DMT. Common GABAa compounds include Alprazolam (Xanax) and Clonazepam (Klonipin).
My personal history with psychedelic mushrooms is varied. i have experienced profound effects from just a small amount of mushrooms, and have also experienced no effect. mushrooms can be some what unreliable as stated above it is difficult to ascertain their how potent they are. one notable experience took place at a local music festival i had attended. i ate an unknown quantity of dried material, approximating to about 2 grams. the onset was subtle but quickly became overwhelming at which point i retreated to my significant others vehicle. the visuals were intense and geometric at first, but then mellowed into dream like closed eye visuals. i imagined myself as a raven, and contemplated the symbolic significance of this animal to my paradigm. on another occasion i had eaten approximately the same amount, but experienced the pure euphoric effects, with only mild visuals. my experiences have been generally positive, though inconsistent. in the future i would prefer to isolate the active compounds through a base/acid extraction to know precisely the amount of psychoactive compound ingested.
Mushrooms are an enjoyable and safe experience despite their inconsistency. i would recommend them for beginners in psychonautical research as they tend to be positive in terms of subjective qualitative effects. Mushrooms are fairly easy to come by depending on region and season, and there is little risk of overdose, eliminating the risk that is inherent in using more powerful psychoactive research chemicals. also Mushrooms have a great deal of research available, so it is possible to get a good perspective of all possible reaction by reading reports from others. the long history of human use is positive, in that it seems to connect ones psyche to the global unconsciousness, and their is a strong sense of contributing to the legacy of human psycho-spiritual experimentation.“
hope it helps